Biological Therapy 



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manner or under unsanitary surroundings the product may 

 become contaminated during processing, causing it to lose 

 its virulency or to undergo chemical changes. It is a grave 

 mistake to assume that all virus is alike or of equal viru- 

 lency because it is produced under inspection. The tech- 

 nique used and attention paid to details of production are 

 the factors which determine freedom from harmful proper- 

 ties and the length of time for which virulency is retained. 

 The value of this can hardly be over-estimated when it is 

 realized that real immunity following simultaneous treat- 

 ment is absolutely dependent upon these factors and that 

 the reputation of the practitioner is at stake each time he 

 administers the treatment. 



PITMAN-MOORE VIRUS 



Every precaution known to modern biological produc- 

 tion is exercised in the production of Pitman-Moore virus. 

 The product is prepared in specially designed buildings of 

 modern hospital construction which are completely isolated 

 in the open country. All animals used in the production of 

 this product are very carefully selected, purchased in the 

 open country and in no instance are animals used which 

 have ever passed through public stockyards. The virus is 

 bled directly from the animal's heart through a sterile can- 

 ula into tightly closed, sterile bottles. It is then mechan- 

 ically defibrinated and at no stage in this process is it ex- 

 posed to the air for even an instant. It is only by exercis- 

 ing these distinctive features and precautions, which are 

 necessarily expensive and in excess of the methods ordi- 

 narily used in virus production, that Pitman-Moore Com- 

 pany is able to offer virus which is free from all pathogenic 

 bacteria, toxins, aggressins or other harmful substances. 



Every serial lot of Pitman-Moore simultaneous virus is 

 tested for virulency on susceptible swine before leaving our 

 laboratories. In addition to this we make certain that all 

 virus retains its virulence for the full length of time for 

 which it is recommended by a second virulency test which is 

 conducted when the virus reaches the date of expiration. In 

 the latter case several susceptible pigs are inoculated with 

 each lot of virus after it reaches its expiration date. There 

 has never been a lot of Pitman-Moore virus so tested which 

 has not proved to be fully virulent after reaching its expira- 

 tion date. We are therefore safe in concluding that if Pit- 

 man-Moore virus is kept under proper conditions and is 



