160 



Biological Tiierapy 



the product contained this organism alone or combined with 

 others. It was further observed that exposed animals which 

 received such a bacterin for prophylaxis did not develop the 

 disease whereas in unvaccinated cattle the incidence was 

 high. In view of these results Hemorrhagic Septicemia Bac- 

 terin (Bovine) is now extensively used for the prevention 

 and treatment of this disease. 



Mastitis in Cattle 



This condition which is ordinarily sporadic sometimes 

 becomes enzootic and affects all available animals in the 

 herd. The affected quarters may undergo sufficient patholo- 

 gical change to completely destroy the functioning ability 

 of the organ, rendering the affected animal valueless for 

 dairy purposes. During the disease the milk flow is ser- 

 iously curtailed and frequently this is followed by a general- 

 ized septicemia which results in death. 



SYMPTOMS. Locally there is swelling and inflamma- 

 tion of the udder in one or more quarters, which may also 

 exhibit tenderness. The duct may become occluded and the 

 milk supply scant. The small amount of milk which is 

 secured is ropy and contains flakes of fibrin or pus. An 

 admixture of blood and pus in the milk is not uncommon. 

 The associated lymphatic glands are swollen and tender and 

 as the toxins from the infected udder are absorbed there is 

 inappetence and fever, while necrosis and gangrene of the 

 affected quarters frequently follows prolonged cases. 



TREATMENT. Bacterins containing the pyogenic 

 streptococcus associated with these cases are generally bene- 

 ficial. Pitman-Moore mastitis bacterin contains 4000 mil- 

 lion bacteria to the dose. This consists of streptococcus 

 sixty percent, staphylococcus thirty per cent, and B. coli ten 

 per cent. All organisms used in this product were carefully 

 selected from cases of mastitis. The dose is two c.c. which 

 should be administered subcutaneously and repeated each 

 three to five days until desired results are obtained. 



In acute cases associated with high temperature and 

 evidence of generalized septicemia good results are obtained 

 with anti-streptococcic serum in doses of fifty to one hun- 

 dred c.c. which should be repeated as indicated. 



