172 



Biological Therapy 



sists of from 500 to 750 units which should be administered 

 subcutaneously as soon as possible after the injury has been 

 inflicted. 



PITMAN-MOORE TETANUS ANTITOXIN 



This product is prepared by hyperimmunizing healthy 

 young horses against the toxin of B. tetani. Beginning with 

 minute amounts of the toxin these frequently repeated in- 

 jections are gradually increased in amount until enormous 

 antibody production is obtained in the blood. When trial 

 bleedings show the antitoxin content of the blood to be 

 sufficiently high, the horses are bled to obtain the serum 

 portion of the blood which contains the antitoxic properties. 

 This is then tested for potency or antitoxic units. Unlike 

 anti-bacterial sera it is possible to determine the unit value 

 of antitoxins. An Antitoxic Unit is the smallest amount 

 of antitoxin which will protect a 250 gram guinea pig against 

 one thousand lethal doses of tetanus toxin. Pitman-Moore 

 Tetanus Antitoxin is unusually high in its antitoxic value as 

 a result of which the volume is small. This is desirable, 

 since it reduces the quantity necessary to inject for a given 

 number of units. Each package contains 30% more units 

 than is indicated on the label, which insures the full unit 

 dosage. After the antitoxin is sterilized and tested it is 

 subjected to the most exacting tests for sterility. 



Tuberculosis and Tuberculins 



This extremely prevalent disease affects practically all 

 species of animals and constitutes the greatest menace of 

 the livestock industry. 



ETIOLOGY. This disease is casued by the bacillus 

 tuberculosis. Three types of this organism have been identi- 

 fied. The human; bovine, which affects cattle and swine; 

 and avian, which affects only fowls. It is felt that the 

 symptoms and lesions of this disease are too well known 

 to require any discussion. 



TREATMENT. Although several different kinds of bac- 

 terins and vaccines have been claimed by various investi- 

 gators to be efficacious for the treatment of affected 

 individuals proper investigation has failed to demonstrate 

 their value, and at this time it is the consensus of opinion 

 that biologies for this purpose are without value. Medicinal 



