976 



THE INTERNAL. SECRETIONS 



mellitus, because the metabolism of the sugars is interfered with in this 

 disease in a much more extensive manner.^ Since the action of 

 adrenaUn seems to be concentrated upon the Hver, it cannot surprise 

 us to find that it also incites a more copious discharge of other products. 

 Thus, Cannon^ has found that the intravenous injection of this agent 

 in amounts of 0.0001 mgr. per kilo of body weight (cats) shortens 

 the coagulation-time of the blood. In addition, it has been shown by- 

 Cannon and Nice^ as well as by Gruber^ that this procedure is followed 

 by a temporary improvement in the power of contraction of fatigued 



Fig. 509. — Median Sagittal Section through Pituitary of Monkey; Semidiagram- 



MATic. {Herring.) 

 a, Optic chiasma; h, third ventricle; c, g, pars intermedia; d, epithelium of pars 

 intermedia extending round neck of pars nervosa; e, pars glandularis seu epitheiialis ; /, 

 intraglandular cleft, lying between pars glandularis (e) and pars intermedia (fir); h, 

 pars nervosa. 



muscles, a change which, owing to the small doses employed, cannot be 

 due to improved circulatory conditions. More recently, it has been 

 pointed out by Hartmann and Eraser^ that subminimal doses of this 

 agent give rise to a vasodilatation. It should be remembered, how- 

 ever, that these effects have been obtained under experimental con- 

 ditions and that they do not justify the deduction that they also occur 

 normally in consequent of the outpouring of var3dng amounts of 

 adrenin. 



1 Lusk and Riche, Arch. Int. Med., xiii, 1914, 673. 



2 Am. Jour, of Physiol., xxxiv, 1914, 255. 



3 Ibid., xxxii, 1913, 44. 



4 Ibid., xxiii, 1914, 335, also: Endocrinology, iii, 1919, 145. 

 6 Ibid., xliv, 1917, 353. 



