980 THE INTERNAL SECRETIONS 



conclusion is strengthened materially by the results of organotherapy. 

 Thus, Robertson 1 has succeeded in isolating a substance which he 

 calls tethelin. It contains nitrogen and phosphorus and exerts a 

 stimulating influence upon the growth of mice. Favorable results 

 have also been obtained by Schafer^ by feeding preparations of the 

 anterior lobe to young rats. Magnus, Levy and Falta report that the 



Fig. 510, — Acromegaly. 

 This man was an acromegalic giant aged thirty-five, with blindness and large tumor 

 of the hypophysis. (Cushing.) 



administration of extracts of the hypophysis increases the decomposi- 

 tion of the proteins. 



G. THE PINEAL GLAND OR EPIPHYSIS CEREBRI 



Position and Function of the Pineal Gland. — ^^In man this structure 

 lies free between the anterior corpora quadrigemina, its base being 

 directed forward across the roof of the third ventricle. In early life 

 it exhibits a glandular appearance and is subdivided by connective 

 tissue septa into lobules which are made up of pale granular cells. 

 At about the seventh year it shows signs of involution, its glandular 



1 Jour, of Biol. Chem., xxiv, 1916, 397, and Schmidt, Jour. Lab. Clin. Med., 

 u, 1917, 719. 



2 Quart. Jour, of Exp. Physiol., v, 1912, 203. 



