I'HKNACKTIN. 81 



and cinchonin had been drilled and obtained a produrl which tln-v 

 called resorcin. This chemical was pt first extolled a^ an antip\ retir 

 also. 



From 18U2 to 1875* there appeared to t>e a cessation of activities i,, 

 the Hold of this class of remedies, hut at the latter dm.- \V. Konigs" 

 gave a new impetus to the work by In*- re^-arches on chinolin, making- 

 it synthetically on a large scale from anilin. He was soon joined in 

 his investigations hy Haeyer. Skraup, Fischer, Knorr, Kornrr. and 

 otlieis. with very fruitful results. 



Doctors Fischer and Konigs in their studies on the alkaloids came- to 

 the conclusion that the properties of quinine did not reside in the 

 quinolin nucleus, hut in an oxygen or hj'drogen-bearing element con- 

 tained in or introduced into the nucleus. With this in mind their 

 researches were prosecuted, and a number of new hodics were discov- 

 ered, only two of which, however, appeared to he succe-^ful as 

 medicinal agents. These were oxyhydromethylchinolin hydrochlorid, 

 prepared by O. Fischer* and called "Kairin," and tetrahydrometh\ 1- 

 quinolin or tetrahydroethylquinolin, made by L. Hoffmann and W. 

 Konigs r and named "Kairolin." The former was patented, highly 

 extolled, and extensive^ advertised, and seems to have been the tirst 

 medicinal chemical that was stimulated by the mercantile influence of 

 letters patent. 



In 1884, L. Knorr d succeeded in preparing another very efficient 

 antipyretic and named it antipyrin. It was well covered by patents. 

 In France, however, a patent was granted only on a process for manu- 

 facturing it as an anilin product. But antipyrin did not possess any 

 industrial value and could not be sold as a patented remedy, for France, 

 in the endeavor to hold the interests of suffering humanity above the 

 interest of the individual inventor, does not grant patents on medicinal 

 agents. The result was that antipyrin was not employed openly in 

 France during the life of the patent. 



Acetanilid was discovered in 1852 by C. Gerhardt/ but its antipy- 

 retic properties were not revealed until 1886, by G. Krieger. r It is 

 well known by its trade name Antifebrin. This compound unfortu- 

 nateh* is prone to induce collapse when frequently administered in 

 large doses. It was shown twenty years previous to this time by C. D. 

 Schroff,* 7 A. Crum-Brown, and T. R. Fraser/' and more recently 



Ber. d. chem. Ges., 1879, 12:453. 



&Ber. d. chem. Ges., 1883, 10:712; Arch. <1. I'liarm. (3), 21: 17. 

 ' Ber. d. chem. Ges., 1883, 16: 727. 



dBer. d. chem. Ges., 1884, 17: 2032; J. Soc. Chen.. Ind.. 1885, 4: 59. 

 Comp. rend., 1852, 34: 755. 

 /Centralb. f. Klin. Med., 1886, 7: 761. 

 ff Wochenblatt d. K. K. Gi*. Aer/tr, Wit-n, 1866, 6: 157. 



* Trans. Royal Soc. Edin., 1867 to 1869, 25: 151 and 693 ; J. Anatomy and Physio!. t 

 (2), 3: 478. 



