INTRODUCTION. 



The first two articles of this bulletin set forth the conditions that 

 prevail not only in relation to individuals, but also in some of the brst 

 regulated laboratories. There is a continual cry for cheaper drugs, 

 and in the effort to meet this demand and at the same time make a 

 profit adulteration has spread. The members of the pharmaceutical 

 profession of high standing, however, are anxious to remove from the 

 trade any odium due to adulteration which at present exists. 



The third paper deals with the patented medicinal remedy phenacetin, 

 which according to reports has been largely adulterated in this country 

 and many substitutes offered therefor. This subject was studied 

 because of the great interest that exists concerning it in both the 

 medical and the pharmaceutical world, many druggists and physicians 

 being directly involved in the controversy. The fact that phenacetin 

 is sold for 15 cents an ounce in Canada, while $1 or more is charged 

 for the same amount in the United States, creates an impression, cor- 

 rect or incorrect, of injustice. The conditions set forth concerning 

 phenacetin are, moreover, typical of those affecting a large number of 

 patented medicinal remedies. Furthermore, the attempts that have 

 been made to secure such changes in the patent laws as would elimi- 

 nate these disturbing factors have not been successful. It is hoped 

 that the contents of this paper will place the whole situation before 

 the public in a just and impartial manner. 



H. W. WILEY, 



Chief of Bureau. 

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