9 



nodules may be felt. When numerous, as described by McFadyean, 

 the lung feels like a bag full of peas. The nodules vary in size 

 from 1 to 5 or 6 millimeters in diameter and on section appear as 

 rounded, grayish areas surrounded by a zone of congestion and 

 often by areas of lobular pneumonia. They always undergo casea- 

 tion or encapsulation. Sometimes they become calcined. 



The diffusely infiltrated lesions in the lungs may form sarcoma- 

 like tumors, which may become so indurated as to form fibroma- 

 like tumors, or they may break down and become gangrenous. In 

 the more chronic cases the lesions may be confined to the lungs 

 alone, or to a testicle or to some internal organ, and the only 

 symptoms present may be a cough or an orchitis, or just a "general 

 loss of condition." These are the cases in which special methods 

 of diagnosis must be employed. 



Chronic glanders is rare in man and is difficult to diagnose. It 

 has been mistaken for chronic coryza. The most common form 

 is due to local infection of an extremity, followed by lymphangitis 

 and subcutaneous and muscular abscesses. In some cases a chronic 

 ulcer or a muscular abscess may be the only evidence of the disease. 

 It may last for months or } r ears and may end in recovery or in the 

 acute form of the disease. 



In farcy the inoculation of the virus usually takes place through 

 some abrasion of the skin. Nodules are then formed in the papil- 

 lary layers of the dermis, in the cutis, and in the subcutaneous and 

 intermuscular tissues. The nodules may turn into abscesses and 

 discharge externally. The neighboring lymphatic vessels are 

 inflamed and swollen, and along their course secondary subcutaneous 

 enlargements are formed the so-called farcy buds. The neigh- 

 boring lymphatic glands are involved, and rarely secondary chronic 

 farcy develops. % Embolic foci form in the spleen, and more rarely 

 in the liver, testicles, kidneys, brain, muscles, heart, and bones. 



In acute farcy in man pains and swelling in the joints and mus- 

 cular abscasses are common. Nasal ulcerations and eruptions on 

 the skin do not usually occur. The acute form is fatal in a large 

 proportion of the cases in from twelve to fifteen days. In the 

 chronic form localized tumors, which undergo abscess formation 

 and ulceration, may be the only symptoms of the disease and may 

 last for months or years and end in recovery or, occasionally, 

 in acute glanders. 



