72 GLANDS IN HEALTH AND DISEASE 



cretion of the gland, feeding with an extract of the 

 gland is followed by no beneficial results at least 

 none that last. 



Brown-Sequard, whose name we shall encounter 

 when we come to discuss the function of the sex 

 glands, did pioneer work on the adrenals as far 

 back as 1856. He removed adrenal glands from 

 44 rabbits, nine guinea-pigs, two rats and several 

 dogs and cats. Not one of these animals survived 

 the operation beyond the thirty-seventh hour. The 

 critics, ever after poor Brown- Sequard, severely 

 criticized his work; they claimed that death in all 

 cases was due to the nature of the operation, and 

 not to the removal of the gland. Brown- Sequard 

 repeated and extended his observations. His con- 

 clusions are shared by the majority of physiologists 

 to-day. Even his claim that partial extirpation 

 does not as a rule result in death has been amply 

 verified. In his over-enthusiasm and Brown- 

 Sequard was a most enthusiastic gentleman he 

 declared that the adrenals were even more impor- 

 tant to well-being than the kidneys themselves. 



Not the least remarkable thing to be noticed in 

 these extirpation experiments is the way the ani- 

 mal will appear quite normal for some time after 

 the operation, and then quite suddenly begin to 

 exhibit effects. Let us illustrate this by giving the 

 protocol in the case of a female Macacus monkey, 

 whose adrenals were removed by Dr. Kahn ( quoted 



