THE ADKENAL GLANDS 73 



by Mathews). The animal weighed a little over 

 four pounds and fed on fruit. "Right suprarenal 

 removed under ether Nov. 9, 1911. The wound 

 heals quickly. On 4 December, 25 days after the 

 operation, when the weight was 62 ounces, took out 

 the left suprarenal. On the fifth the animal is very 

 well and eats heartily. On the sixth she eats with 

 normal appetite. Is active. There is a little edema 

 (swelling) at the edges of the wound. On the 

 seventh, normal. On the eighth, normal, but appe- 

 tite a little less. On the ninth at 9 a.m. is fairly 

 weak, lies stretched out on the bottom of the cage ; 

 no appetite; wound in best state. At 9:12 a.m. 

 great increase in prostration. Apathetic. The eyes 

 are open and look about. At 1:45 p.m., being 

 nearly moribund, was killed with chloroform. The 

 liver was examined for glycogen ; only a trace was 

 found. The animal lived five days. For four days 

 it could not be told from a normal animal. The 

 sudden onset of the symptoms of extreme depres- 

 sion has the appearance of an intoxication." 



Why the "normalcy" for some days after the 

 operation, and then the sudden change for the 

 worse, is not at all clear. Perhaps the body has 

 a hormone reserve that holds out for four days 

 and then gives out. 



Addison's disease. The equivalent or what is 

 supposed to be the equivalent of the removal of 

 the adrenals may be seen in man in Addison's dis- 



