THE ADRENAL GLANDS 77 



ullary portion disappears altogether. Some ex- 

 perimenters have recorded temporary successes, 

 but nothing that as yet warrants much optimism. 

 Jaboulay, a French surgeon, transplanted the 

 adrenals of a dog into a patient suffering from 

 Addison's disease. The surgeon does not tell us 

 what happened to the transplanted gland, but he 

 does record that the patient died within 24 hours! 

 Dr. Voronoff might reply that one of two reasons 

 would explain this : either the surgeon was a bun- 

 gler and did not perform the operation skillfully 

 enough; or, what is more probable, the adrenal 

 of a dog cannot replace that of man. Biology 

 and chemistry certainly have taught us that 

 "specificity" is a distinguishing feature of many 

 dynamic reactions. In any case, before we con- 

 demn adrenal grafting, many more such experi- 

 ments will have to be performed. 



Hyper-adrenalism. Neither is our information 

 less obscure with regard to conditions where there 

 is an excessive production of the adrenal hormone 

 here again in striking contrast to our knowledge 

 of hyper-thyroidism. "The whole subject," writes 

 Vincent, an eminent English authority, "is very 

 obscure and requires further and continuous inves- 

 tigation." 



The cortex. To what extent our ignorance of the 

 entire subject of the adrenal glands is due to our 

 ignorance of the part played by the cortex of the 



