130 GLANDS IF HEALTH AND DISEASE 



cannula (tube for inserting into body) was inserted 

 in the large pancreatic duct and the drops of se- 

 cretion recorded. The blood pressure in the caro- 

 tid (the principal artery in the neck) was also 

 recorded. The animal was in a warm saline bath, 

 and under artificial respiration. 



"The introduction of about 20 cubic centimeters 

 (about 1-25 of a pint) or about one tablespoon of 

 four-tenths per cent, of hydrochloric acid x into the 

 duodenum (the first portion of the small intestine) 

 produced a well-marked secretion of one drop every 

 20 seconds, lasting for some six minutes; this re- 

 sult merely confirms previous work. But and 

 this is the important part of the experiment, and 

 the turning point of the whole research the in- 

 troduction of 10 cubic centimeters of the same acid 

 into the enervated loop of jejenum produced a 

 similar and equally marked effect. 



"Now, since this part of the intestine was com- 

 pletely cut off from nervous connection with the 

 pancreas, the conclusion was inevitable that the 

 effect was produced by some chemical substance 

 finding its way into the loop of jejenum in question, 

 and being carried in the blood stream to the pan- 

 creatic cells. Wertheimer and Le Page have shown, 



1 Hydrochloric acid is found in the stomach under normal con- 

 ditions. It is approximately four-tenths of one per cent, in 

 strength. Of course the object in introducing the acid is to 

 prove that it, and it alone, coming from the stomach, liberates 

 the hormone in the intestine. 



