210 GLANDS IN HEALTH AND DISEASE 



Epoch-making experiments on the effects of the removal 

 of the thyroid. 



P. J. Mobius: Schildruse theorie (Schmidts Jahrbiicher, 



volume 210, page 237, 1886). 



The opinion is expressed that Basedow's disease depends 

 on an abnormally increased activity of a ductless gland. 



P. Marie: "Sur deux cas d'acromegalie, hypertrophie sin- 

 guliere non congenitale des extremites superieures, in- 

 ferieures et cephaliques (Revue de mededne, page 298, 

 1886). 

 The discovery that acromegaly is a disease due to the 



pituitary. 



Brown-Sequard : "Des effets produits chez 1'homme par des 

 injections sous-eutanees d'un liquide retire des testi- 

 cules frais de cobaye et de chien" (Comptes rendus de 

 la societe de biologie, volume 41, page 415, 1889). 

 "Brown- Sequard injected the juice of the testicle sub- 

 cutaneously into his own body and observed an increase in 

 corporeal and mental powers that he attributed to the 

 influence of these injections." The beginning of modern 

 organotherapy, or treatment by means of glandular ex- 

 tracts. 



J. von Mering and 0. Minkovski : "Diabetes mellitus nach 

 Pankreas exstirpation" (Archiv fur experimentelle 

 Pathologie, volume 26, page 371, 1889). 

 The complete removal of the pancreas results in severe 



diabetes. 



