COMPILED DATA UNDER GREEN TABLE NUMBERS. 61 



rh tinctorial power that 1 ounce will color 2,000 pounds of candy to the highest y el- 

 tint required in his business. It is obvious that the toxicity of such a body would 

 ve to be very high to render it harmful in such use." Conclusions of this kind do 

 t take into account the possible detrimental action ensuing on healthy as well as 

 jeased persons from long-continued' use of small quantities of foreign substances. 



Page 909.) The same author raises objection to feeding experiments on the ground 

 at substances are thereby introduced greatly in excess of the amounts generally 

 und in foods and that the ill effects "are liable to be due to the excess and in long- 

 ntinued experiments due to a cumulative action of the excess. ' ' Surely if excessive 

 lounts have a cumulative action, small amounts may also finally show toxic effects 

 e to retention and accumulation of the poison. To declare a substance entirely 

 nocuous would require evidence as to its nontoxicity both to normal and diseased 

 rsons after its long-continued administration in both small and large doses. The 

 >st extreme contingencies would have to be provided for. The above objections to 

 eding experiments are therefore not valid. It is hoped that a study of the effects 



metabolism of some of these substances will help to further elucidate the subject. 



He summarizes the results of his physiological investigations of 

 ven different coal-tar colors as follows: 



1. Several commercial organic dyestuffs (Curcumin S, Tartrazin, Naphthol Red S, 

 smnois in B, Naphthol Yellow S, Gold Orange, and Ponceau 2 R) were studied as 



their general effects on dogs when administered in varying amounts and during 

 rly long periods (two weeks). 



2. None of these dyestuffs under the conditions above indicated exhibited any 

 wked degree of toxicity. There was only one fatal result, which may have been 

 e to influence independent of the action of the colorant. 



Similar quotations from the literature could be added to the fore- 

 ing, but these are beyond question sufficient to show that a wide 

 vergence of opinion as to the harmless or harmful nature of the 

 al-tar colors as a class does exist among scientific men, and that all 

 ose above quoted agree that there are some at least of the coal-tar 

 lors which even in a pure state may be harmful to human health, 

 nd that the question of actual harmfulness under the conditions 

 actual use in foods and the consumption of foods is regarded by 

 me as being properly answered in the negative and by others as 

 ling properly answered in the affirmative. The question of amount 

 color employed in the food products and the amounts of such food 

 >rmally eaten are therefore raised by some as the deciding factors. 

 In this connection the following statement from page 49 of the 

 guments before the Committee on Patents in the House of Kepre- 

 ntatives, April 8, 15, 16, 22, 29, 1908, may be of interest: 



* * It should be remembered that after a new chemical has been discovered 

 d patented it requires as many as three years of experiment before we dare offer it 

 n this country as a medicine for human beings. These experiments are conducted 

 abroad before we receive it here. It is first tried on animals and gradually, with great 

 :aution, extended to human beings in the foreign hospitals, so as to ascertain its 

 >hysiological effects quantitatively upon the various organs, both when those organs 

 ire in the healthy state and when they are affected by various disorders * * *. 



