80 COAL-TAR COLORS USED IN FOOD PRODUCTS. 



2. CAZENEUVE AND LEPINE (Compt. rend., 1885, v. 101, pp. 1167-1169) Continu* 



per 100 pounds; for the 10 days next succeeding it received daily twice the lael 

 amount, or 266 milligrams per kilogram of body weight, that is, 186 grains pe 

 100 pounds. It received altogether in the 25 days 62 grams, or 964 grains 

 There was no vomiting, no diarrhea, and no albumen in the urine at an; 

 time." 



3. WEYL (p. 31): "* * * not poisonous to human beings and dogs: Naphthc 



YellowS. * * *." 



Weyl describes his own experiments on 3 dogs, giving them, respectively 

 417, 34, and 100 milligrams per kilo body weight, or per 100 pounds 292, 24 

 and 70 grains, respectively. Whether the color was administered by the mouth 

 or injected subcutaneously, all bodily functions appeared to remain normal 

 and it was only in the case of repeated doses of 417 milligrams per kilogran 

 of body weight, or 292 grains per 100 pounds, that albuminuria appeared 

 (pp. 89-92.) 



4. "Only the sulphonated colors Naphthol Yellow * * * are harmless and appli 



cable to the coloring of food and drink." (p. 96.) 



5. Permitted by the laws of Austria. 



6. Permitted by the law of Italy. 



7. Permitted by the law of France. 



8. SCHACHERL (p. 1044): "* * * Naphthol Yellow S * * * possesses no poi 



eonous properties." 



9. FRAENKEL (p. 572): "Naphthol Yellow S is an entirely nonpoisonous substance.' 



10. MEYER (/. Amer. Chem. Soc. 1907, v. 29, p. 900): One hundred milligrams pe: 



kilogram of body weight for the initial administration, and subsequent admin 

 istrations increased geometrically. After the second administration intermit 

 tent diarrhea resulted, emphasized by increased amounts with no albumin o: 

 sugar in the urine; continued for 14 administrations; so that in 14 administra 

 tions 147.58 grams of color had been given; the initial dose is 70 grains per 10( 

 pounds of body weight, and the average daily dose of the total administered 

 is 394 grains per 100 pounds of body weight. Urine only slightly yellow col 

 ored after small doses, but red after larger doses. 



11. LIBBER (p. 143): A dog received 36 milligrams per kilogram of body weight, o: 



25.2 grains per 100 pounds once a day seven times every other day; during th< 

 whole period the dog was apparently in good condition with no bad effect 

 from the color. 



12. Buss lists it as nonpoisonous. 



13. CAZENEUVE AND LEPINE (Compt. rend., 1885, v. 101, pp. 1167-1169): Thre< 



chronic invalids received daily from 2 to 4 grams of the dye in cochets; excep 

 slight colic and diarrhea nothing abnormal. 



DOUBTFUL. 



1. LEWIN (Lehrbuch der Toxikologie, 1897, p. 232): "Acid Yellow S is said to be abl< 



to produce dermatitis on frequent contact therewith." 



2. WINOGRADOW (Zts. Nohr. Genussm., 1903, v. 6, p. 589) says it noticeably retardf 



digestive action; is not indifferent. 



G. T. 5. 



Trade name. Brilliant Yellow; Naphthol Yellow S or RS. 

 Scientific name. Dinitro-alpha-naphthol-alpha-monosulphonicacid 

 Discovered and patented. 1884. 

 Shade. Yellow. Not offered. 



