90 COAL-TAR COLORS USED IN POOD PRODUCTS. 



FAVORABLE. 



1. Permitted by Confectioners' List. 



2. WEYL (p. 115): "Bordeaux Red (Fast Red B) not poisonous to human beings." 



3. "Other Azo colors * * * Fast Red B * * * are entirely nonpoisonous." 



(p. 148.) 



4. FRAENKEL (p. 575): "That the monoazo coloring matters examined by Cazeneuve 



and L6pine, as already above stated, are nonpoisonous, can be easily explained 

 by the constitution of these substances. These two investigators examined 

 * * * Bordeaux B." 



5. ARLOING AND CAZENEUVE (Archives de physiologic, 1887, pp. 356-393): As a result 



of this work, which is divided into three parts (1) Stating the effect of direct 

 introduction of the color into the circulation; (2) intravenous injections; (3) 

 comparing the effects of injections of color and of salt; and (4) feeding by the 

 mouth these investigators conclude that these coloring matters are toxic only 

 in extremely large doses; that when given to dogs with their food that no incon- 

 venience of any kind results; this is based upon experiments on three dogs, 

 covering 145 days, where each dog received per kilogram of initial body weight 

 in the first case 20,307 milligrams, or 14,213 grains per 100 pounds initial body 

 weight; in the second case, 29,590 milligrams, or 20,713 grains per 100 pounds 

 initial body weight; and in the third case, 28,154 milligrams, or 19,758 grains 

 per 100 pounds initial body weight. Per day this means 98 grains per 100 

 pounds initial body weight in the first case; in the second case, 143 grains per 

 100 pounds initial body weight; and in the third case, 137 grains per 100 pounds 

 initial body weight. 



6. CAZENEUVE (Arch. gen. de med., 1886, p. 753) says it may be taken without effect 



by man or animals, sick or well, in large doses. 



7. CAZENEUVE AND LEPINE (Bull, de Vacad. de med., 1886, p. 643): Tolerated by man 



well or sick. 



G. T. 70. 



Trade name. Azarin S. 



Scientific name. Ammonium bisulphite compound of dichloro- 

 phenol-azo-beta-naphthol. 

 Shade. Red. Not offered. 



FAVORABLE. 



1. Permitted by Confectioners' List. 



2. WEYL (p. 115): "Nonpoisonous * * * Azarin S * * *." 



3. Experiments on five dogs; three fed by the mouth; two treated hypodermically, 



of which latter one died. The first dog received 1,367 milligrams per kilogram 

 body weight in 25 days; that is, 54.7 kilograms per day on the average, or a total 

 of 957 grains per 100 pounds of body weight; that is, 38 grains per 100 pounds 

 body weight per day. The second dog received a total of 1,942 milligrams per 

 kilogram body weight in 20 days, or 97 milligrams per kilogram body weight per 

 day, which amounts to a total of 1,359 grains per 100 pounds body weight, or 68 

 grains per 100 pounds body weight per day. In both cases a distinct amount of 

 albumen was present in the urine, and the urine evolved sulphurous acid on treat- 

 ment with hydrochloric acid. The third dog received hypodermically three 

 doses in eight days, each dose being 213 milligrams per kilogram body weight; 

 that is, 149 grains per 100 pounds body weight; no bad effects, (p. 133.) 



3. "Administered by the stomach Azarin S is harmless. " (p. 134.) 



4. "Other Azo colors, * * * for instance Azarin S, are entirely nonpoisonous." 



(p. 148.) 



5. FRAENKEL (p. 578) : "Azarin S administered by the stomach is entirely harmless. " 



