COMPILED DATA UNDER GEEEN TABLE NUMBERS. 



101 



2. CHLOPIN (Zts. Nahr. Genussm., 1902, v. 5, p. 241} Continued. 



to disappear; the urine was colored throughout the period of dosing, and it was 

 not until 10 days after the last color had been administered that the urine 

 regained normal color; otherwise the animal was well throughout. B. Hu- 

 mans: Two hundred milligrams, or 3-^ grains taken at 3 p. m., October 30, 

 1901, colored the urine so highly yellow that it could be dyed with. Apart 

 from the bitter taste of the product no untoward symptoms are recorded. C. 

 Chlopin's conclusion (Zts. Nahr. Genussm., 1902, v. 5, p. 244): "Metanil Yellow 

 is not poisonous to dogs in doses of from 2 to 3 grams per day, nor to humans 

 in doses of 0.2 grams per day, and may therefore perhaps be regarded as non- 

 poisonous from a practical point of view." 



UNFAVORABLE. 



1. WEYL (p. 115): ''Poisonous * * * Metanil Yellow." 



2. Says the product smelled strongly of diphenylamin. (p. 130.) 



3. A. "Metanil Yellow must be considered poisonous when administered by the 



stomach from the indications of Experiments 1 and 2. The lethal dose, which 

 is determined by Experiment 2, is 0.53 grams per kilo body weight." This 

 lethal dose is 371 grains per 100 pounds body weight. B. A dog received 862 

 milligrams per kilogram body weight, or 603 grains per 100 pounds body weight. 

 This caused vomiting; the same dose was repeated 24 hours afterwards, the 

 animal again vomiting. The animal died within 96 hours from the first admin- 

 istration. C. A dog received 89 milligrams per kilogram body weight, or 62 

 grains per 100 pounds body weight; the urine became colored about 96 hours 

 after administration; 5 days after the first administration the animal was given 

 10 times the original dose; vomiting set in within one hour; in 24 hours the 

 urine was deeper colored; a week later after the dose last preceding, one-half 

 of that dose was given, and the animal died within 24 hours; the animal had 

 lost during this period approximately one-quarter its original weight, (p. 132.) 



4. "* * * Metanil Yellow * * * produce[s] such effects when administered 



by the stomach that we can consider them [it] poisonous." (p. 147 '.) 



5. "The poisonous qualities of * * * Metanil Yellow; the poisonous Metanil 



Yellow." (p. 148.) 



6. FRAENKEL (p. 578): "A dog weighing 11 kilograms was killed by 20 grams of 



this coloring matter within four days, whereas the isomeric Diphenylamin 

 Orange is nonpoisonous, and it must first be considered if the poisonous nature 

 of this substance can be explained by the easy liberation of diphenylamin 

 from it, since this coloring matter, in and of itself, has a strong odor of diphenyla- 

 min." 



7. CHLOPIN (p. 141)'- Based on his own experiments considers it "Not quite harm- 



less." The experimental data are as follows: 



Experimental data by Chlopin. 

 [1 gram = 153 mg = 107 grains.] 



