106 COAL-TAR COLORS USED IN FOOD PRODUCTS. 



FAVORABLE. 



1. CAZENEUVE AND LEPINE (see Weyl, p. 115}: Not poisonous to human beings. 



3. LIBBER (p. 148): A rabbit received 284 milligrams per kilogram body weight, or 



199 grains per 100 pounds once a day, five times every other day, and aside from 



decreased appetite the second and third day of the observation period nothing 



untoward is noted. 

 4 WEYL (p. 31): "* * * not poisonous to human beings and dogs, * * * 



Purple * * *" 

 5. CAZENEUVE AND LEPINE (Bull de Vacad. de med., 1886, p. 643): Tolerated by man, 



sick or well. 



G. T. 138. 



Trade names. Fast Brown G; Acid Brown. 



Scientific name. Sodium salt of bi-sulphobenzene-disazo-alpha- 

 naphthol. 



Discovered. 1882. 



Shade. Brown. Not offered. 



FAVORABLE. 



1. WEYL (p. 134): "The following is a summary of the results obtained with the Dis- 

 azo colors submitted to test by me, viz, Fast Brown G * * *. All these 

 proved to be nonpoisonous * * *." A. A dog weighing 9.63 kilos received 

 312 milligrams per kilogram body weight, or 218 grains per 100 pounds body 

 weight; the same dose was repeated 48 hours afterwards, when diarrhea set in, 

 and the urine was colored red; 24 hours afterwards 208 milligrams per kilogram 

 body weight, or 146 grains per 100 pounds body weight were given; the urine 

 was colored strongly red 24 hours thereafter. Eight days afterwards 520 milli- 

 grams per kilogram body weight, or 364 grains per 100 pounds body weight, were 

 administered; marked diarrhea set in; 3 days later the dose given was twice the 

 dose last given, when severe diarrhea resulted, but unchanged color appeared in 

 the urine, and continued for 24 hours afterwards ; diarrhea continued for 96 hours. 

 Evidences of albuminuria apparently not dependable. B. A second dog, 

 weighing 5.9 kilos, received 339 milligrams per kilogram body weight, or 237 

 grains per 100 pounds body weight daily throughout an entire month; diarrhea 

 was produced after 6 days, which continued almost during the month; appetite 

 was diminished and the loss in weight was about 20 per cent on the original. 

 C. Weyl concludes as follows: "According to these experiments, this color 

 in continuous, though slight, doses, or in large doses, but less frequently, 

 produces diarrhea, anorexia, and emaciation." (p. 136.) 



UNFAVORABLE. 



1. Prohibited by Confectioners' List. 



2. WEYL (p. 147): "Of the remaining colors * * * others (produce) diarrhea 



(Fast Brown * * *)." 



G. T. 160. 



Trade name. Crocein Scarlet 3 B; Ponceau 4 RB. 

 Scientific name. Sodium salt of sulphobenzene-azo-benzene-azo- 

 bet a-naphthol-monosulphonic acid . 

 Discovered and patented. 1881. 

 Shade. Scarlet. Not offered. 



