COMPILED DATA UNDER GEEEN TABLE NUMBERS. 109 



2. "Naphthol Black P, however, is plainly poisonous when introduced into the sub- 

 cutaneous cellular tissue." (p. 147.} 



G. T. 197. 



Trade names. Bismarck Brown; Phenylene Brown; Leather 

 Brown; English Brown; Manchester Brown; Vesuvin; Cinnamon 

 Brown. 



Names under which it was offered on the United States market as a 

 food-color in 1907. Vesuvin 4B Cone. Z; Bismarck Brown; Bismarck 

 Brown B No. 216; Bismarck Brown B. 



Scientificname. Hydrochloric! of benzene-disazo-phenylene-diamin, 



Discovered and patented. 1863. 



Shade. Reddish brown. Offered by 4 out of 12 sources. 



FAVORABLE. 



1. WEYL (p. 115): " Nonpoisonous Bismarck Brown." 



UNFAVORABLE. 



1. Prohibited by Confectioners' List. 



2. WEYL (p. 117): A. A dog received 33 milligrams per kilogram body weight, or 



23 grains per hundred pounds body weight; in one and one-half hours, vomiting; 

 next day same dose same result with the addition that the animal took no food 

 and moved about but little for 48 hours; on the fourth day same dose, in two 

 hours, vomiting; for 96 hours animal took no food; on the eighth day albumen 

 in the urine and the animal ate; on the ninth day 83 milligrams per kilogram 

 body weight or 58 grains per 100 pounds body weight, vomited for one-half hour 

 after administration; for the next 5 days the animal took hardly any food; on 

 the fourteenth day the animal improved, took food on the fifteenth day; traces of 

 albumen in urine for 17 days longer, at end of which time animal recovered. 



B. A dog received 169 milligrams per kilogram body weight, or 118 grains per 

 100 pounds body weight; in 24 hours the urine was colored brown; 48 hours 

 after the first dose that dose was repeated, and unconverted color was found 

 in the urine; 48 hours later the same dose was repeated; the color in the urine 

 disappeared in 24 hours; 4 days later the dose was trebled, and the animal 

 vomited, seemed sick for 4 days thereafter; on the fifth day recovery apparently 

 complete. On the sixth day the last dose was repeated, and the animal vomited 

 after the administration. It took no food for 24 hours, and was normal after 

 48 hours. There was no albuminuria in this case. 



C. A dog received daily for an entire month 45 milligrams per kilogram body 

 weight, or 31| grains per 100 pounds body weight; it was in good health during 

 the entire time, did not vomit, and ate as usual. Its gain in weight was 6J 

 per cent. 



3. "Bismarck Brown produces, when administered to dogs by the stomach, even 



in doses of 350 milligrams per kilogram body weight (245 grains per 100 pounds 

 body weight), vomiting and albuminuria. Further disturbance is not noted 

 even in large doses; small doses, 45 milligrams per kilogram body weight (or 

 31 J grains per 100 pounds body weight), even when frequently administered 

 seem to be entirely harmless. Doses of 16 milligrams are harmless even when 

 introduced into the subcutaneous cellular tissue." (p. 118.) 



4. "Of the remaining colors some produce vomiting (e. g., Bismarck Brown 



* * ). (p. 147.) 



