COMPILED DATA UNDER GREEN TABLE NUMBERS. 



143 



9. GALLIARD (Rev, intern, des falsifications; abst. Ilygien. Runsdach. 1892, p. 104}'. 

 "Methylene Blue, which is frequently used for coloring foods, can cause, even 

 in small doses (10 to 20 milligrams, or one-sixth to one-third of a grain), a feel- 

 ing of general depression, nausea, and certain feelings of pain, and can even 

 produce transitory albuminuria. In larger doses (40 to 60 milligrams, or six- 

 tenths to nine- tenths of a grain), it causes in the case of persons not accustomed 

 thereto, vomiting, diarrhea, increased micturition, and albuminuria. In the 

 case of persons suffering from nervous diseases, it frequently produces disturb- 

 ance which has as its consequence a cessation or a change of place of the pain. 

 Sometimes it produces painlessness, or an easing of pain in the patient, for 

 which no certain therapeutic indication could be determined." 



10. WEYL (Handbuch dcr Hygiene) comments as follows: "These statements of Gal- 



Hard arouse but little confidence, because, as is well known, Methylene Blue 

 is very frequently administered to invalids in doses of more than 0.5 gram 

 without any noticeable disturbance. Perhaps Galliard's preparation was 

 unclean. At any rate, in all experiments on the poisonous nature of Methylene 

 Blue it is to be considered that it frequently occurs in commerce as a zinc 

 chlorid double salt." 



11. LEWIN (Lehrbuch der Toxikologie, 1897, p. 232}: "Methylene Blue * * * can 



produce after prolonged administration of 0.5-1.5 gram daily increased micturi- 

 tion, irritation of the bladder, blue coloration of the urine, and saliva, diarrhea, 

 headaches, vertigo, delirium, and twitching of the muscles, the latter symp- 

 toms probably because the coloring matter is deposited in the brain." 



12. Buss lists it as poisonous. 



G. T. 651. 



Trade name. Methylene Green G cone, extra yellow shade- 

 Scientific name. Nitromethylene Blue. 

 Discovered and patented. 1886. 

 STiade. Green. Not offered. 



Nothing. 



FAVORABLE. 



UNFAVORABLE. 



1. THLOPIN (pp. 192-193} examined this color, and on his own experiments concludes 

 that it is "nonpoisonous, but somewhat suspicious." The experimental data 

 are as follows: 



Experimental data by Chlopin. 



Xo. 1. 

 [1 gram=71 mg=50 grains.] 



