DOSAGE AND SYMPTOMS. 155 



(6) Also that if 198 grains produce no effect the color is to be 

 lassed as harmless, even if 582 grains in another case kill the animal. 



(c) That if small amounts produce albuminuria and larger amounts 

 not the color is to be classed as harmless. 



(d) That if small amounts produce diarrhea and larger amounts 

 [do not the color is to be classed as harmless. 



From Class III it would appear that 



(a) Albuminuria produced by as little as 1 17 grains is to be regarded 

 las not harmful. 



(b) Diarrhea produced by 70 grains is to be regarded as not harmful. 



(c) Vomiting and albuminuria produced by 127 grains are to be 

 | regarded as not harmful. 



The colors classed as harmful in the Confectioners' List may be 

 I classified as follows : 



I. Dogs. Those colors that under certain conditions produce no 

 I noticeable effects on dogs, while under other conditions effects are 

 | observed, are classed as harmful colors: 



1. Picric Acid: 



Dogs stand 5 grains daily for 18 days without effect. 

 18 grains produced diarrhea. 

 20.4 grains killed. 



2. Dinitrocresol: 



140 grains caused vomiting but did not kill. 

 38$ grains caused vomiting but did not kill. 

 38$ grains caused vomiting and did kill. 



35 grains caused vomiting but did not kill. 

 31.6 grains caused vomiting but did not kill. 



3. Martius Yellow: 



51 grains do not kill, but produce weakness, diarrhea, and albuminuria. 

 50 grains kill. 



8 grains do not kill, but produce weakness, diarrhea, and albuminuria. 

 Orange II: 



714 grains produced kidney irritation, thirst, and diarrhea. 

 333 grains kill, and produced diarrhea and albuminuria. 

 244 grains produced kidney irritation, thirst, and diarrhea. 



36 grains produced no effect. 

 95. Metanil Yellow: 



620 grains produce vomiting. 

 603 grains kill. 

 407 grains no effect. 

 371 grains kill. 



104 grains produced albuminuria. 

 62 grains no effect. 

 41 grains no effect. 

 31 grains kill. 

 197. Bismarck Brown: 



246 grains produced vomiting. 



118 grains produced vomiting and general depression. 



38$ grains daily for 30 days, no effect. 



