FIRST STUDIES ON ANAPHYLAXIS 15 



possession of a sure means of killing sensitised guinea- 

 pigs. Now, taking into consideration the regularity 

 with which the prepared guinea-pigs succumbed to the 

 cerebral test, we were enabled to make certain that 

 those which resisted this test owed their survival not 

 to mere chance, but in reality to anti-anaphylactic 

 immunity artificially induced. This assurance, which 

 neither intraperitoneal nor, still less, subcutaneous 

 injection was able to afford us — the majority of the 

 guinea-pigs showing themselves to be naturally re- 

 sistant to injection by these routes — was guaranteed 

 us by the intracerebral method. 



From the time of publication of our first mono- 

 graph in 1907 the study of anti-anaphylaxis has been 

 our primary object. It was also our principal aim 

 in the memoirs that followed in the period covered 

 by the years 1907 to 191 2, when we devoted our- 

 selves to the study of various methods of producing 

 anti-anaphylaxis and the mechanism of its produc- 

 tion. But, for the sake of clearness of exposition we 

 shall now abandon chronological sequence, and in 

 order to facilitate an understanding of phenomena, so 

 numerous and so varied as those of anaphylaxis, we 

 shall deal with these phenomena in combination with 

 the three main properties, the sensitising, the toxiC; 

 and the anti-anaphylactic. 



