26 ANAPHYLAXIS AND ANTI-ANAPHYLAXIS 



phylactic symptoms such as attacks of vomiting, 

 diarrhoea, collapse, micturition, dyspnoea, abolition 

 of the reflexes, etc. 



Evidently the serum of the dog that had been first 

 injected contained the anaphylactic antibody which 

 we have termed sensibilisin, to which Charles Richet 

 gave the name of toxogenin. 



Passive anaphylaxis possesses the same charac- 

 teristics and the same specificity as active, with this 

 difference — namely, that it is produced at the outset, 

 that is to say, instantaneously. 



Owing to the researches of Doerr^ and his colla- 

 borators, the technique of passive anaphylactisation 

 is at the present date considerably simplified. 



A rabbit is injected twice or three times with 

 several days' intervals with serum, milk, or some 

 other substance against which it is desired to obtain 

 sensibilisin. These injections are made indifferently 

 either subcutaneously, intraperitoneally, or intra- 

 venously. Six days after the last injection the rabbit 

 is venesected and its serum collected . In the majority 

 of cases it is sufficient to inject i c.c. of it into a fresh 

 guinea-pig, in order that it may become hypersensi- 

 tive at the first onset to the substance which had been 

 injected into the rabbit that supphed the serum. 



Passive anaphylaxis has been produced with bac- 

 teria by Kraus and Amiradzibi,^ Briot,^ and Dopter, 

 Briot and Dujardin-Beaumetz;^ with pancreatic juice 

 by Nicolle and Pozersky ;^ with tuberculin, antipyrin, 

 and iodoform by Bruck.^ We shall return to this 

 subject in the chapter dealing with bacterial and 

 therapeutic anaphylaxis. 



^ Zeitschr. f. Immunitatsf. I. Orig., 1909, iii., pp, 181 and 706. 



2 Ihid., I. Orig., 1910, iv., p. 607, 



3 Compies rend. Soc. de Biol., 1910, Ixix,, pp. 10 and 126. 

 * Comptes rend. Soc. de Biol., 1910, Ixix., p. 14. 



5 Ibid., 1910, Ixviii., p. 1113. 



^ Berl. klin. Wochenschr., 1910, xlvii., p. 192. 



