CHAPTER V 

 VACCINATING OR ANTI-ANAPHYLACTIC INJECTION 



Experiments on the destruction of the toxic substance of sera 

 by chemical and physical agents — Attenuation of the toxi- 

 city of sera by heating to ioo°, 95°, 89°, 76° C. — Effect of 

 repeated heating at 56° C. — Effect of narcotics (ether, 

 alcohol) on the production of anaphylactic shock in guinea- 

 pigs — Experiments on vaccination against the so-called 

 toxin contained in sera — Rapid vaccination by a single 

 injection against anaphylactic shock — Vaccination by 

 graduated small doses — ^Vaccination against local anaphy- 

 laxis — Vaccination against anaphylactic shock in the 

 course of immunisation of horses with bacteria (gono- 

 coccus, meningococcus, diphtheria bacillus, streptococcus, 

 etc.) — The method of Auer and Ascoli for dealing with ana- 

 phylactic accidents — Application of the method of grad- 

 uated small doses in man: choice of method — Anti-ana- 

 phylaxis by the digestive tract — Summary of various anti- 

 anaphylactic processes; their respective value — Mechanism 

 of anti-anaphylactic vaccination. 



In view of the marked resemblance which exists 

 between anaphylaxis in the guinea-pig and the 

 symptoms which immediately follow serum inocu- 

 lation in man, we set ourselves to discover, from the 

 beginning of our researches on anti-anaphylaxis 

 {1907), by what means the guinea-pig could be 

 preserved from anaphylactic shock. We hoped thus 

 to reach the solution of the problem which we had 

 most at heart — viz., the checking of serum siTTkness 

 in man. 



The problem before us might a priori be attacked 

 on two sides : on one side we could endeavour to 

 attenuate the toxicity of sera for injection; on the 

 other we could endeavour to produce in the animal 

 an immunity against sera. 



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