64 ANAPHYLAXIS AND ANTI -ANAPHYLAXIS 



saved, thanks to this process, but immunisation is 

 effected in a more regular manner. Thus, on former 

 occasions the temperature rose slowly and remained 

 high for three or four days. After the use of ana- 

 phylactic vaccinations the temperature rises imme- 

 diately, but falls almost invariably within eighteen 

 hours. The general condition is good; the animal 

 preserves its appetite and vivacity, which Vv^as not 

 the case before the appUcation of this process. Ciuca 

 noted that anaphylactic symptoms were particularly 

 frequent in dysenteric horses in the course of im- 

 munisation with whole cultures. Out of seven horses 

 thus immunised, six died with classical symptoms. 

 Each injection was followed by a rise of temperature 

 (39° C), anorexia, and occasionally diarrhoea. Since 

 the employment of anti-anaphylactic injections, none 

 of these troubles have been observed. The tempera- 

 ture rises to 39°-40° C, but it does not remain at 

 that level for more than twelve hours. The general 

 condition remains good during the whole time. To 

 sum up, the method of small doses constitutes, 

 according to Ciuca, a most efficacious means of pre- 

 venting lethal symptoms in the course of immunisa- 

 tion; it much reduces the febrile period, and almost 

 completely abolishes the bad general condition which 

 ordinarily persists some days after the injection of 

 large doses of bacteria. Such are the facts relating 

 to anti-anaphylactic vaccination in animals. 



How can anti-anaphylactic accidents be avoided 

 in man ? 



We will not here lay stress upon the numerous 

 attempts made by different workers to destroy the 

 so-called " toxic substance " of sera. We have 

 already spoken of it elsewhere, and the question is 

 now settled. 



Let us here recall the method recommended by 

 Auer. It consists in a preventive administration of 



