VACCINATING INJECTION 69 



case is very urgent and if you think that each hour 

 which passes robs the patient of the chance of 

 recovery, carry out the anti-anaphylactic vaccination 

 intravenously. Begin by diluting the serum (5 c.c, 

 for example) in six times its volume of physiological 

 saline solution; inject i c.c. of this solution intra- 

 venously at the bend of the elbow. According as the 

 patient reacts or not, wait three to five minutes ; if 

 he does not react, then inject 3 c.c. of this same 

 solution. If he does not exhibit any untoward 

 symptom, you reinject 10 c.c. two minutes after- 

 wards: finally, after another interval of two minutes, 

 you will make the last injection, employing 25 c.c. 

 of solution. From that time your patient may be 

 regarded as vaccinated against anaphylactic mishaps. 

 As we have been able to assure ourselves in a great 

 number of cases, the patient is in a position to receive, 

 ten minutes afterwards, an intravenous or intrathecal 

 injection of 10 to 30 c.c. of pure undiluted serum. 



These graduated small injections, which follow at 

 a few minutes' interval, can be performed without 

 its being necessary to withdraw the needle from the 

 vein. These few examples are sufficient to enable 

 the physician to familiarise himself with regard to 

 the mode of anti-anaphylactic vaccination to be 

 adopted in each particular case. 



If the case is one of cerebro-spinal meningitis or 

 any other disease, he has only to remember that it 

 requires — 



{a) Three or four hours to obtain anti-anaphy- 

 lactic vaccination subcutaneously; 

 (6) One to two hours for intraspinal injection ; 

 (c) Ten minutes to a quarter of an hour for 

 intravenous inoculation. 



We have now to say a few words on anti-anaphy- 

 laxis by way of the digestive tract. 



In the course of our researches on anaphylaxis with 



