82 ANAPHYLAXIS AND ANTI-ANAPHYLAXIS 



question of crystallin — namely, those of Morax and 

 Bollak.^ The result of their study goes to shew that 

 (i) an animal sensitised with the crystallin of another 

 species reacts almost always to reinjection of crystallin 

 of this species, and, furthermore, very often reacts 

 quite as well to this as to the homologous crystallin 

 of its own species ; (2) that the animal does not react 

 to the injection of serum of the same species. 



From the point of view of anaphylaxis crystalHn, 

 therefore, seems to be in possession of quite special 

 properties; it possesses the specificity of the organ 

 and not of the species. In other words, the animals 

 injected with the crystallin of another species do not 

 react to serum of the same species; on the contrary^ 

 they are hypersensitive to all crj'-stalhn irrespective 

 of species. 



Animals sensitised with human semen^ react 

 anaphylactically to semen of the same species. In 

 order to produce shock, the reinjection should be 

 made with a massive dose, and directly into the 

 heart. The reaction fails when the injection is made 

 with semen of another species or with serum of the 

 same species. 



In this anaphylaxis, in the presence of semen, there 

 exists, therefore, in the case of sera, simultaneous 

 specificity both of organ and of species. 



To sum up, from the point of view of anaphylactic 

 reaction, in the case of organs such as the liver, spleen, 

 and heart, there does not appear to be specificity; 

 in the case of crystallin there is specificity of organ 

 and not of species ; in that of semen there is simul- 

 taneous specificity of both organ and species. 



In the course of this account allusion has already 

 been made to the question of congestin, to which 



* Annates de I'Institut Pasteur, xxviii., p. 625, 1914. 



* Minet et Leclercq, Comptes rend. Soc. de Biol., Ixx., p. 506, 

 1911. 



