ADDITIONAL EXAMPLES OF ANAPHYLAXIS 87 



that it is the reverse of this in the really characteristic 

 anaphylactic process. 



Another characteristic, none the less important, 

 which may serve as a criterion of an anaphylactic 

 condition, consists in the facility with which anti- 

 anaphylactic immunity is obtained. But Nefedoff 

 has not succeeded in conferring this immunity on 

 guinea-pigs which he had sensitised with cholera 

 vibrios. We may note, by the way, that in this 

 latter report Nefedoff's experiments do not agree 

 as to results with those of Delanoe. 



These few facts are sufficient to shew how in- 

 definite the subject of bacterial anaphylaxis is, and 

 how much it needs to be supported by fresh researches. 



Passive anaphylaxis has likewise been the subject 

 of numerous researches . It is to Kraus^ and his fellow- 

 workers that we are indebted for the first experiments. 



A rabbit received increasing doses of typhoid 

 bacilli. Fifteen days after the last injection it was 

 bled, and it was as interesting as it was unexpected 

 to find that its serum appeared to be capable of 

 conferring passive anaphylaxis on a fresh guinea-pig 

 in the presence of typhoid bacilli. 



Indeed, it was only necessary to inject a fresh 

 guinea-pig with 3 c.c. of this serum the day previous 

 for this animal the next day to be in a state of 

 bacterial anaphylaxis ; one dose of the typhoid bacilli 

 injected intravenously, which only killed the control 

 after the lapse of several hours, immediately set up 

 in the injected guinea-pig symptoms of anaphylaxis 

 which terminated fatally in a few minutes. 



The same phenomena can be observed when a 

 mixture is made in vitro of bacilli and the serum 

 in question, and the whole is injected subcutaneously 

 into a fresh guinea-pig. 



This anaphylaxis which is transmitted to the 

 ^ Zeitschr. f. Immunit^tsf., I. Orig., iv., p. 607, 1910. 



