88 ANAPHYLAXIS AND ANTI-ANAPHYLAXIS 



guinea-pig by the serum of the prepared rabbit is 

 strictly specific, and on that point opinions are not 

 divided, contrary to what obtains in the case of 

 passive bacterial anaphylaxis. 



Passive anaphylaxis has been produced by Briot 

 and Dopter^ in the case of the meningococcus with 

 antimeningococcic serum; by Briot and Dujardin — 

 Beaumetz^ in the case of the plague bacillus with 

 antiplague serum; by Nefedoff' in the case of the 

 cholera vibrio with the corresponding serum. 



Having had occasion to witness the sudden death 

 of horses in the course of immunisation b^^ intravenous 

 injection, we have been compelled to establish, even 

 before Kraus,^ an analogy between these mishaps and 

 those which characterise anaphylactic shock. We 

 have even gone further, and have asked ourselves 

 whether in the case in which our interference would 

 be justified it would not be possible to avoid these 

 mishaps by the application of the procedure of anti- 

 anaphylactic vaccination. The experiments made, as 

 has already been seen, have justified our conjectures.^ 



The special sensitiveness of tuberculous subjects 

 to the injection of tuberculin is a well-known fact. 

 Is this anaphylaxis ? At first sight one would be 

 strongly inclined to believe it. But upon reflection 

 we find that several features, and these by no means 

 of the least importance, are here lacking. 



Our present knowledge tells us that an animal 

 which is in a state of anaphylaxis contains an ana- 

 phylactic antibody or sensibilisin. Now, all attempts 

 to discover the presence of this antibody in the serum 

 of tuberculous subjects were unavailing up to the 

 time when Bail® carried out his experiments. 



1 Comptes rend. Soc. de Biol., Ixix., p. to, 1910. 



2 Ibid., p. 14. 3 Ibid., Ixxiv., p. 672, 1913. 



* Ibid., Ixvii., p. 266, 1909. ' See Chapter V. 



• Zeitschr. f. Immunitdtsf., I. Orig., iv., p. 470, 1910; Ibid., 

 xii., p. 451, 1912. 



