ADDITIONAL EXAMPLES OF ANAPHYLAXIS 89 



This worker states that when an emulsion of 

 tuberculous tissues is injected into a fresh guinea-pig 

 the animal rapidly becomes hypersensitive to the 

 tuberculin; if twenty hours afterwards, or even later, 

 this guinea-pig is injected with tuberculin, grave 

 symptoms are set up which may terminate fatally. 

 Control experiments made with emulsion of normal, 

 non-tuberculous organs remained negative . The same 

 result is obtained when a guinea-pig is injected with 

 an emulsion of normal organs to which tubercle 

 bacilli are added. In neither of these two cases is 

 so much as a trace of hypersensitiveness to tuberculin 

 proved. Consequently it is only tuberculous organs 

 that possess the power of transmitting passive ana- 

 phylaxis to tuberculin; these organs are therefore the 

 carriers of the anaphylactic antibody or sensibilisin. 



Bail's experiments appeared to be decisive, and 

 the problem would have been considered as settled 

 once for all had not other experimenters been im- 

 pressed with the impossibility of reproducing these 

 experiments. 



Thus, Joseph^ has endeavoured to produce passive 

 anaphylaxis with the serum of tuberculous sheep. 

 It is known that these animals are particularly 

 sensitive to tuberculin; it is sufficient to inject them 

 with a minimal dose (o-oooi c.c. of tuberculin) to 

 witness a rise of temperature to a marked degree. 

 Now, in spite of this great sensitiveness peculiar to 

 tuberculous sheep, it was found possible to inject 

 their serum at will into nine guinea-pigs without 

 giving rise to the appearance in the latter of even the 

 slightest degree of sensitiveness to the tuberculin. 



We may add that Bail's experiments have been 

 confirmed by Onaka, but they have completely failed 

 at the hands of Kraus, Loewenstein, and Volk.^ 



^ Zeitschr. f. Immunitatsf., I. Grig., iv., p. 575, 1910. 

 2 Deutsche med. Wochenschr., xxxvii., p. 389, 191 1. 



