ADDITIONAL EXAMPLES OF ANAPHYLAXIS 91 



greater. As a result of this second injection the 

 mortality was as great among the guinea-pigs that 

 had been vaccinated as among those that had not 

 been so treated. 



To sum up : The tuberculin reaction shews no 

 clinical resemblance to anaphylactic shock ; its appear- 

 ance does not follow the injection either of fluid 

 tuberculin or of the bodies of tubercle bacilli; it is 

 not accompanied by the appearance of the anaphy- 

 lactic antibody; and, lastly, it cannot be influenced 

 b}'' anti-anaphylactic measures. 



For all these reasons, in spite of the phenomena 

 which favour its anaphylactic nature, the tuberculin 

 reaction should be considered, pending fresh informa- 

 tion on the subject, as dependent on a poison sui 

 generis of special activity in tuberculous subjects. 



Before bringing this chapter to a conclusion we 

 have yet to mention some researches bearing upon 

 the so-called drug anaphylaxis. 



Clinicians have long been aware of cases of intoler- 

 ance for certain drugs without being able to explain 

 them save by bestowing upon them the specious title 

 " idiosyncrasy." The arrival of the era of anapiiy- 

 laxis has opened up a fresh horizon to their view. 



It is to Bruck^ that we are indebted for pioneer 

 experiments dealing with this question. He reported 

 the case-history of an individual who was peculiarly 

 susceptible to iodoform. An application of iodoform 

 in ether had the effect of producing a swelling and 

 redness of his scrotum and penis, and a rise of tem- 

 perature (39-7° C), followed by a haemorrhagic erup- 

 tion covering the pubic region and the upper part of 

 the thighs. 



This patient's serum was injected into three guinea- 

 pigs. Two other control guinea-pigs were used, one 

 ' Berl. klin. Wochenschr., xlvii., p. 1928, 1910. 



