92 ANAPHYLAXIS AND ANTI-ANAPHYLAXIS 



being given the same dose of serum derived from a- 

 normal subject, and the other horse serum. The 

 next day the author injected five guinea-pigs with an 

 equal quantity of iodoform (0-33 gr. per kilogramme 

 for each animal). Whilst the two control guinea-pigs 

 failed to shew any abnormal symptom, the three 

 others injected with the patient's serum exhibited 

 very pronounced symptoms of anaphylaxis . 



The serum of the patient in question therefore 

 contained, in Bruck's opinion, anaphylactic anti- 

 body to iodoform, and this enabled him to transmit 

 passive anaphylaxis to iodoform to fresh guinea-pigs. 

 A similar observation on the subject of intolerance 

 to antipyrin has been published by the same author. 

 Tlie person who suffered from this intolerance — he 

 was a medical man — ^was bled, and his serum injected 

 into a guinea-pig. Another guinea-pig was injected 

 under the same conditions with the serum of a normal 

 subject. The next day the two guinea-pigs, and two 

 others as well, were injected with antipyrin. Only 

 the guinea-pig which had been injected with the 

 serum of the medical man exhibited anaphylactic 

 symptoms (which ended fatall}^); the other three 

 guinea-pigs remained in a perfect state of health. 



This experiment, the nature of which is so curious,, 

 has but one fault : it is unique. 



Our collaborator Cruveilhier^ has endeavoured to 

 bring this problem within the region of experiment. 

 He sensitised guinea-pigs by injecting them intra- 

 peritoneally with 6 centigrammes of antipyrin. A 

 fortnight or three weeks later he tested them by 

 intracerebral injection (25 centigrammes). Out of 

 twenty-two guinea-pigs thus treated, seventeen died 

 in less than twelve hours ; in five of these death was 

 preceded by violent convulsions, restlessness, dys- 

 pnoea, and the passage of urine. Out of nineteen 



1 Comptes rend. Soc. de Biol., Ixxi., p. 223, 191 1. 



