ADDITIONAL EXAMPLES OF ANAPHYLAXIS 93 



control guinea-pigs injected subdurally with the same 

 dose of antipyrin, three died in less than eighteen 

 hours, but with symptoms that differed unquestion- 

 ably from anaphylactic shock ; all the others survived. 



In addition, Cruveilhier was successful in sensitising 

 guinea-pigs passively; this was effected by injecting 

 them with rabbit's serum which had been prepared 

 by repeated injections of antipyrin. 



Lastly, in four cases sensitised guinea-pigs were 

 enabled to resist the test injection by means of anti- 

 anaphylactic vaccination (method of small doses) 

 carried out shortly before the test. 



Manoiloff's^ experiments have been carried out 

 with the serum of six persons who manifested a pro- 

 nounced intolerance to sodium bromide and of three 

 individuals peculiarly sensitive to quinine sulphate. 



Blood was withdrawn from these various indi- 

 viduals at the particular time of their exhibiting 

 symptoms of intolerance. Their serum was injected 

 into guinea-pigs and rabbits in doses of 3 to 5 c.c. 

 The experiments shewed that doses of bromide and 

 of quinine which were harmless in the case of normal 

 animals proved toxic and sometimes rapidly lethal 

 in the case of animals injected with sera derived from 

 the individuals in question. This was especially 

 marked in the case of quinine, which had a fulminating 

 action on animals passively anaphylactised. 



It need hardly be stated that the animals injected 

 with the serum of normal individuals suffered from 

 no untoward symptoms upon receiving the same 

 dosage of sodium bromide or of quinine sulphate. 



Practical applications of the anaphylactic reaction 

 have not been made on an extensive scale. In 

 certain cases such application may be of real service. 

 From the outset of our researches we pointed out the 

 -advantage which may be derived from it. We 

 * Zeitschr.f. Immunitdtsf., I. Grig., xi., p. 425, 1911. 



