THEORIES RELATING TO ANAPHYLAXIS 103 



Seitz^ obtained anaphylotoxins with the pneumo- 

 coccus, the diphtheria bacilhis, the streptococcus, 

 and the staphylococcus. Marcora^ obtained it with 

 Trypanosoma nagana. Lastly, Friedberger^ has 

 brought complement into contact with tetanus toxin, 

 and has obtained a tetanus anaphylotoxin lethal to 

 the guinea-pig, when injected intravenously, in from 

 three to eleven minutes. 



According to Friedberger and his numerous skilled 

 assistants, all these anaphylotoxins play a primary 

 part not merely in anaphylaxis, but even in the course 

 of bacterial infections in general. In the opinion of 

 these authors it is the anaphylotoxins and not the 

 endotoxins, as has hitherto been believed, that 

 dominate the whole symptomatology of infectious 

 diseases, including tetanus. 



Neufeld and Dold,* experimenting on similar lines 

 with the typhoid bacillus, the cholera vibrio, and the 

 pneumococcus, have not been slow in arriving at this 

 point of view. 



In his monograph devoted to the study of bacterial 

 anaphylotoxins,^ Dold has summarised all these 

 researches as follows : " The researches that have been 

 carried out on anaphylotoxins have contributed 

 greatly to the comprehension of infective processes." 

 A little farther on he says: " We agree with Fried- 

 berger in considering that it is to these toxic products 

 that are due in large measure the general phenomena 

 observed in the course of various infections." Lastly, 

 at the end of his description of the anaphylotoxins 

 this author comes to the conclusion that, " thanks 

 to these recent researches, we are in a position to 



1 Zeitschr. f. Immunitatsf., I. Grig., xi,, p. 588, 1911. 



2 Ibid., xii., p. 595, 1912. 



3 Berl. klin. Wochenschr., xlviii., p. 1880, 191 1. 

 * Ibid., xlviii., p. 55, 191 1. 



fi " Das Bakterien- Anaphylotoxin und seine Bedeutung fur die 

 Infektion," Jena, p. 80, 1912. 



