THEORIES RELATING TO ANAPHYLAXIS 113 



best known. As we have already indicated above, 

 their actual manner of formation has nothing in 

 -common with the conditions which govern the pro- 

 duction of the anaphylactic shock. 



That is not all. It must be remembered that the 

 phenomenon of anti-anaphylaxis, which is the specific 

 attribute of all anaphylactic phenomena, does not 

 apply at all to the anaphylotoxins. Thus, our 

 collaborator Sukiennikowa^ has discovered that 

 guinea-pigs sensitised to egg-albumen, then vaccinated 

 by means of small doses, are as sensitive to the injec- 

 tion of the anaphylotoxin prepared with egg-albumen 

 as the non-vaccinated control guinea-pigs. 



Elsewhere we have seen that anaphylotoxins are 

 only fatal in intravenous injections. 



With Stroebel and Jupille we have observed that 

 this deadly action of the anaphylotoxins is completely 

 annulled by a previous injection of peptone ; we have 

 been able to prove it both for the serous anaphylo- 

 toxin and the tj'^phoid anaphjTotoxin.^ 



Must it not be concluded from all these facts that> 

 like all the other so-called anaphylactic poisons 

 brought forward, Friedberger's anaphylotoxins have 

 a very different mode of action, and that their action 

 depends, very probably, upon their properties of 

 coagulation? The disturbances observed by Fried- 

 berger and others, which end very soon in death 

 from asphyxia, would prove, in reality, symptoms of 

 embolism and not of anaphylaxis. 



Being unable, at present, to bring forward more 

 direct proofs, we present the following hypothesis, 

 which all the facts so far established seem to confirm. 



It is implied in all the theories we have just re- 

 viewed that the anaphylactic shock is due to a 

 special poison, this poison being, according to Charles 



Zeitschr. f. Immunitatsf., I. Orig., xvii., p. 304, 1913. 

 2 Annales de Vlnstihit Pasteur, xxvii., p. 185, 1913. 



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