132 ANAPHYLAXIS AND ANTI-ANAPHYLAXIS 



Anaphylaxis, confusion as to 

 meaning of word, 117 



— death wrongly attributed to 

 in guinea-pig, ix 



— discovery, vii 



— first studies on, 5 



— in presence of tissue extracts, 

 question of specificity, 79, 80 



of various substances, 



78 



— in vitro, example of, 83 



— local, in rabbit, following sub- 

 cutaneous injections of serum, 

 milk, or egg-albumen, 39 



— — vaccination against, experi- 

 mental work, 60, 61 



— mechanism of production, re- 

 cent work on, 126 



— onset of, primary cause, 5, 11, 

 114 



— origm, vii 



— passive 24 



— — production in rabbit, 26 

 production of, substances 



used for, 26 



— phenomena of, described, 2, 3 



general characters, i 



in guinea-pigs, 3 



— quasi-paradoxical character, 2 



— recent work on, 1 17-130 



— sensibiUsin present in animals 

 in state of, 90 



— serum sickness distinct from, 

 119 



— symptomatology of tuberculin 

 reaction not typical of, 90 



— true nature of, 125 

 Anaphylotoxin, chemistry of, 100 



— formation of, 98, 99 

 how prevented, 99, 100 



— injection of, sensitiveness of 

 guinea-pigs to, 113 



— intracerebral injection without 

 toxic efEect, 100, 104 



— production of, method, 100 

 Anaphylotoxins, 128 



— active, method of preparation, 



105 



— bacterial, injection itito guinea- 

 pigs, effect, 102 



production of, 102, 103 



— constitutionof , neither antigen, 

 antibody, nor complement in- 

 dispensable for, 105, 106 



— disturbances set up by, cause 

 of, 112 



— existence denied, 114 



— lethal action, 1 1 3 

 — how annulled ,113 



Anaphylotoxins, phenomenon of 

 anti-anaphylaxis does not apply 

 to all, 1 1 3 



Animal inoculated, rather than 

 protein used, determines ana- 

 phylactic signs and symptoms, 



Anti - anaphylactic measures, 

 tuberculin reaction uninfluenced 

 by, 90, 91 



Anti-anaphylaxis, cases to which 

 term should be applied, 75 



— onset of, primary cause, 115 



— opposition to conception of, 75 



— phenomenon of, does not apply 

 to all anaphylotoxins, 113 



— production of, alleged cause, 

 109 



— reason for adoption of term, 75 



— specific character denied, 75 

 Antibody, anaphylactic, connex- 

 ion with body cells, 129 



— and antigen, union of, result, x 



— disappearance in presence of 

 anti-anaphylactic immunity, 74 



— formation of, ix, x 



— not indispensable for produc- 

 tion of anaphylotoxin, 106 



— precipitating, and sensibilisin, 

 parallelism between, 10 1 



appearance and disap- 

 pearance of sensibilisin in serum 

 at same time as that of, 10 1 



— produced during sensitisation 

 of serum, 18. See also Sensi- 

 biligen 



Antidysenteric sera, horses used 

 for preparation of, injected with 

 small doses, 63, 64 



Antigen, addition in sufficient 

 quantity to neutralise sensibi- 

 lisin causing anaphylactic state, 



76. 77 



— and antibody, unionof, result, X 



— combination of sensibilisin with 

 causing anaphylactic shock, 96, 



97 



— not indispensable for produc- 

 tion of anaphylotoxin, 106 



— precritical dose of, 77 



— slow neutralisation of sensi- 

 bilisin by, anti-anaphylactic 

 immunity dependent on, 115, 

 116 



Antigens, anaphylactic substances 

 assumetl to act as, 126 



Anti-meningococcic serum, injec- 

 tion producing passive ana- 

 phylaxis, 88 



