140 ANAPHYLAXIS AND ANTI-ANAPHYLAXIS 



Rabbits sensitisation with repeated 

 injections of horse serum sub- 

 cutaneously, 6i 



• pre- 

 ceded by small injection intra- 

 venously, 6 1 



— symptoms of anaphylactic 

 shock in, 39 



Ranzi, experiments on anaphy- 

 laxis in presence of tissue 

 extracts, 79 



— sensitisation of guinea-pigs 

 with tissue extracts, 79 



Rashes in serum sickness, 119 



— secondary, in acute infectious 

 diseases, 123, 124 



Rectum, vaccination , by way of, to 

 induce abolition of anaphylactic 

 state, 70, 71 



Rice, extracts of, anaphylaxis 

 experiments with, 84 



Richet, Charles, anaphylaxis ex- 

 periments with congestin, 82, 83 



with crepitin, 83 



cause of death in ana- 

 phylactic shock in dog, 40 



difficulty of production of 



experimental alimentary ana- 

 phylaxis, 18 



effect of injection of, 



actino-congestin into sensitised 

 dog, 6 



injection experiment with 



sensibiUsin, 25, 26 



nature of anaphylactic 



shock, 97 



oral vaccination by means 



of crepitin, 71 



and Portier, discovery of 



anaphylaxis by, vii 



Rosenau and Anderson, causes 

 of sudden death following in- 

 jection of horse serum, 11 



complete disappearance 



of toxicity of sera at boiling- 

 point, 45 



experimental work on 



anaphylaxis, 9 



vaccination experiments 



against so-called toxin in sera, 50 



Roux, preface to " Anaphylaxis 

 and Anti-anaphylaxis," vii 



Sausages, manufactured from 

 different kinds of meat, ana- 

 phylaxis experiments on guinea- 

 pigs with macerations of, 94, 95 



Schern, employment of anaphy- 

 lactic reaction in discovery of 



adulteration of vegetable pro- 

 ducts, 94' 



Schultz and Massini, sensitisation 

 of guinea-pig's intestine, 125 



Seitz, method of preparation of 

 dysentery anaphylotoxin, 105 



Semen, anaphylaxis in presence 

 of, 82 



— human, animals sensitised with 

 react anaphylactically to semea 

 of same species, 82 



— possesses specificity of both 

 organ and species, 82 



SensibiUgen, 114, 128 



— and sensibiUsin, rate of coming 

 into contact and place of meet- 

 ing, relation to anaphylaxis and 

 anti-anaphylaxis, 114 



union, cause of toxicity 



of serum, milk, and egg-albu- 

 men, 41 



— dose of, time of production of 

 sensibiUsin dependent on, 28 



— injection of, result, 27 



— isolationin pure state, attempts 

 at, 20 



— production of, 18 



— thermostability of, 20, 21 

 SensibiUsin, 114, 128 



— and precipitating antibody, 

 parallelism between, loi 



— appearance and disappearance 

 in serum at same time as 

 precipitating antibody, loi 



— combination with antigen 

 causing anaphylactic shock, 96, 



97 



— disappearance in presence of 

 anti-anaphylactic immunity, 74 



— effect of injection of serum 

 containing into dog, 25, 26 



— formation of, time needed for, 

 28 



— neutraUsation by addition of 

 sufficient quantity of antigen, 



76. 77 



— not yet demonstrated in case 

 of tuberculin, 90 



— presence in animal in state of 

 anaphylaxis, 88 



— production of, 25, 27 



— slow neutralisation of, by 

 antigen, anti-anaphylactic im- 

 munity dependent on, 115, 116 



— time of appearance in body. 



Sensitising group resulting from 

 protein digestion, destruction 

 by normal digestion, 121 



