INDEX 



141 



.Sera, anallergetic, 65 



— antibacterial and antiendo- 

 toxic, method of obtaining, 62 



— French, feeble toxicity of, 



44. 45 



— hsemolytic, powerful, method 

 of obtaining, 62 



— therapeutic, bacteria must be 

 absent from, 33 



degree to which heated 



at Pasteur Institute, 48 

 giving rise to anaphylactic 



symptoms in guinea-pigs must 



be discarded, 34 



non-toxicity important, 33 



percentage of carbolic acid 



permissible in, 33 

 testing of, 33 



— toxic, use to be forbidden in 

 treatment of human subject, 33 



power of, thermolabile, 22 



— substance of, attempts at 



destruction by chemical and 



physical agents, 44 



— toxicity of, attenuation on 

 heating to lower temperatures 

 than boiling-point, 46, 47 



complete disappearance at 



boiling-point, 45 



decrease after venesec- 

 tion, 32, 34 



diminished by high 



temperature, 34 



on injection reduced by 



heating, 53 



quantitative estimation by 



injection into guinea-pigs by 

 intracranial route, 34 



reduction without im- 

 pairing therapeutic or pro- 

 phylactic qualities, 46, 47 



— toxin in, so-called, rejection 

 of hypothesis of, 52 



— — vaccination experi- 

 ments against, 50 



— various, toxicity of, 31 



difference between, 31 



mode of determining, 



31 

 Serum accidents, rarity in France 



48 

 — age of, as factor in toxicity, 



31. 32. 34 



— anaphylaxis, bacterial ana- 

 phylaxis analogous to, 129, 130 



local, vaccination of con- 

 junctiva against, 54 



symptoms, in ox and horse, 



40 



Serum, anaphylaxis, true, condi- 

 tions in man resembhng, 121 



— and typhoid bacilli, injection 

 into guinea-pig, 87 



— antidiphtheritic, guinea-pigs 

 employed*! or testing of, exhibit- 

 ing sensitiveness to horse serum, 



8,9 



— antitetanic, injection by spinal 

 route, recommended, 121 



injection, in man, ana- 

 phylaxis following, 120 



— appearance and disappearance 

 of sensibilisin in at same time 

 as precipitating antibody, loi 



— containing sensibilisin, effect 

 of injection into dog, 25, 26 



— diluted and unheated, lethal 

 to sensitised guinea-pigs on 

 injection, 45, 46 



heat-resisting character of 



sensitising property of serum 

 more marked in case of, 19 



— dossier for records of kinds of 

 serum purchased, 65 



— fastness, 123 



— fresh injection of, sudden 

 death following, 2, 3 



— heated, injection of, protects 

 against anaphylactic shock, 



53 



— injection in repeated small 

 doses protecting against ana- 

 phylactic shock, 57 



— injection in repeated small 

 (loses protecting against ana- 

 phylactic shock, tested experi- 

 mentally in guinea-pigs, 57, 

 58 



— injections, anaphylactic symp- 

 toms following, patient's past 

 history as to, 67 



— of tuberculous sheep, injection 

 into guinea-pigs with negative- 

 results, 89 



— rash, successive crops of, 

 suggested significance, 126 



— sensitisation of, antibody pro- 

 duced during, 18. See also 

 Sensibiligen 



of guinea-pigs with, weak 



doses necessary to produce 

 rapid effect, 16, 17 



— sensitising function, attempts 

 at deprivation, 20 



property of, heat-resisting, 



18, ig 



— sickness, distinct from ana- 

 phylaxis, 118, 119 



