142 ANAPHYLAXIS AND ANTI-ANAPHYLAXIS 



Serum sickness folIo\ving injec- 

 tions, in cerebro-spinal menin- 

 gitis, 66. 68 



in children, first observation 



of, 8 



in man, symptoms, 40, 41, 



119 



gravity of, 41 



— subcutaneous injection into 

 rabbit followed by local ana- 

 phylaxis, 39 



— symptoms, occurring among 

 Tartars, probable cause of, 18 



— test injection, by intracerebral 

 route, reasons for preference, 



29, 30 

 by intravenous route, 



advantages and disadvantages, 



29 

 and intracerebral 



routes in guinea-pigs, results 



compared, 30 

 into sensitised animal, 



modes of carrying out, 29 



— tests in researches on cellular 

 theory of anaphylaxis, 125 



• — toxicity, cause of, 41. See also 

 Dromedary serum, Goa^s serum, 

 Horse serum. Sheep's serum 



Sheep, sensitiveness to tuberculin, 

 89 



— tuberculous, serum of, injection 

 into guinea-pigs with negative 

 results, 89 



Sheep's serum, animals sensitised 

 to, hypersensitive to tissue ex- 

 tracts of sheep, 79 



Shock, anaphylactic, an intoxica- 

 tion, not true shock, 97 



produced in dog by injec- 

 tion of crepitin and sensitised 

 serum from another dog, 83 



symptoms of, in guinea- 



pig. 38 



— probably a cellular phenome- 

 non, 129 



Smith. Theobald, experimental 

 work on anaphylaxis, 9 



Sodium bromide, anaphylaxis ex- 

 periments on guinea-pigs with, 



93 



intolerance to, 93 



Spinal anaphylaxis, in guinea- 

 pigs, protection against, by 

 injection in small doses, 66, 67 



production, 66 



— route, recommended for injec- 

 tion of antitetanic serum, 120, 



Spleen of anaphylactic guinea- 

 pigs, changes in small arteries, 

 127 



Stanculeanu and Nita, vaccina- 

 tion of conjunctiva against 

 local serum anaphylaxis, 54 



Staphylococcus, anaphylotoxins 

 from, 103 



Status lymphaticus, condition re- 

 sembling, in serum sickness, 41 



Streptococcus, anaphylotoxins 

 from, 103 



Tartars, violent serum symptoms 



occurring among, probable cause 



of, 18 

 Temperatures, high, toxicity of 



sera diminished by, 34 

 Tetanus anaphylotoxin, 103 

 lethal on injection into 



guinea-pig, 103 



— toxin must be absent from 

 therapeutic sera, 33 



— See also Serum, antitetanic' 

 Thermolability of toxic power of 



sera, 22 

 Thermostability of egg-albumen, 23 



— of sensibiligen, 20, 21 



— of sensibiligen of milk, 21 

 Thrombi and agglutinate masses 



of corpuscles, plugging of pul- 

 monary bloodvessels with 

 (pseudo-anaphylaxis) ,118 



Tissue extracts, anaphylaxis in 

 presence of, question of specifi- 

 city, 79, 80 



of sheep, animals sensitised 



with sheep's serum hyper- 

 sensitive to, 79 



sensitisation of guinea-pigs 



with, 79 



not specific, 



79 



Toxin in sera, so-called, rejection 

 of hypothesis of, 52 



vaccination experi- 

 ments against, 50 



Toxins, absence from therapeutic 

 sera important, 33 



Toxogenin. 28 



Trypanosoma nagana, anaphylo- 

 toxins from, 103 



Tuberculin, hypersensitiveness to, 

 production in guinea-pig, 89, 

 90 



— injection of tuberculous guinea- 

 pigs with, results, 90, 91 



— reaction, on what dependent, 

 91 



