AN EXPERIMENTAL ANALYSIS OF OEDEMA 7 



added to the lymph is thereby made available for excretion 

 by the kidneys. 



The chief significance of the above-mentioned experiments 

 is that we have demonstrated by experiment that a subcutane- 

 ous oedema can be produced in a frog by a purely mechanical 

 block in the drainage system, and that the location of the 

 block determines the place and extent of the oedema. 



The writer has found that a subcutaneous oedema is in- 

 variably accompanied by the intracellular (interstitial?) 



TABLE 1 



Showing gain (per cent) in body weight in same living frog or toad, in which 



the ureters have teen ligated, when successively placed in 



tap-water at different temperatures 



Percentages based on original weight of frogs and toads. 



oedema, in which lymph accumulates, in excess of normal, 

 in or among the cells of the tissues. After a frog, whose leg 

 has been ligated, has remained for about twenty-four hours 

 in water, the gastrocnemius muscle of the ligated leg may be 

 greatly swollen and, when removed from the body, is found 

 to weigh considerably more than that of the leg which has 

 not been ligated. The abnormal increase in size and weight 

 of the muscle from the ligated leg, over that of the muscle 

 from the leg not ligated, is undoubtedly due to the presence 

 of lymph in excess of normal, which, in some manner, has 



