AN EXPERIMENTAL ANALYSIS OF OEDEMA 



11 



pressure less water was required than when the frog had 

 been desiccated prior to the injection. 



The above experiments show the general osmotic reactions 

 which take place in a living frog placed in water after the 

 concentration of salts in the body and, consequently, the 



12 1. NaCl (2 97%) 

 li 



NaClCz.^v.) 



lo- 



12- 



M 



lfc 

 IS 



2 

 Hours 



3 10 U 14 1& 1% 20 22 2+ Z& 23 30 



36 



Fig. 1 Behavior of a normal desiccated frog when placed in water at different 

 temperatures (curves 1, 2, and 3) ; behavior of same frog when desiccated, after 

 a saline solution has been injected into the subcutaneous lymph sinuses and the 

 frog placed in water (curve 4) ; behavior of same frog, not desiccated, after a 

 saline solution has been injected into the subcutaneous lymph sinuses and the 

 frog placed in water (curve 5) ; behavior of same frog which has contracted 

 red-leg disease during the course of the experiment (curve 6). 



osmotic pressure of the body fluids have been raised above 

 normal. Let us now consider the behavior of muscles taken 

 from desiccated frogs when these muscles are immersed in 

 a Ringer's solution approximately isotonic with muscles of 

 a normal, healthy frog that has not been desiccated. 



It has long been recognized that the weight of a resting 

 muscle taken from a normal healthy frog remains practically 



