AN EXPERIMENTAL ANALYSIS OF OEDEMA 



17 



and intramuscular fluids, and in the fluids in which the mus- 

 cles are immersed. 



In two of the ligated bullfrogs it is interesting to note the 

 presence of an abnormal and excessive accumulation of lymph 

 in the coelom, a portion of the body not shut off by a ligature 

 from the general circulation. Such an accumulation of lymph 



TABLE 3 



Behavior of gastrocnemius muscles from normal healthy frogs, in lymph from 

 oedematous subcutaneous lymph sinuses of ligated legs of other frogs. 



Control: Behavior of gastrocnemius muscles from same frogs, in Ringer's solu- 

 tion approximately isotonic with normal resting muscle. 



Ringer's solution: A = 0.445° — pH, 7.0. Room temperature. 



in the coelom (ascites) indicates that, in addition to the 

 oedema in the leg, an oedematous condition has been estab- 

 lished throughout the remaining portion of the body. This 

 implies that more water is entering the subcutaneous lymph 

 sinuses through the integument than can simultaneously be 

 excreted by the kidneys. In these frogs the osmotic pressure 

 of the lymph would necessarily be below what we ordinarily 

 regard as normal. 



