24 



CHARLES F. W. MC CLURE 



ized swelling of the right leg, and in addition the entire body 

 is generally and uniformly swollen. In the latter, therefore, 

 we have a case in which a localized as well as a generalized 

 subcutaneous oedema has been developed in the same indi- 

 vidual — a condition which, as previously mentioned, can be 

 simultaneously produced in the living frog by applying a 



Fig. 2 Photograph of a frog with red-leg disease, showing a localized subcu- 

 taneous oedema of right thigh. 



ligature to the thigh and by ligating the ureters. The pres- 

 ence of a localized and a generalized oedema in the same indi- 

 vidual suggests the possibility that, as in the case of the 

 double-ligation experiment, the cause of the localized swell- 

 ing may be influenced by local rather than by general con- 

 ditions; otherwise the lymph would be more uniformly dis- 

 tributed throughout the subcutaneous lymph sinuses. 



