AN EXPERIMENTAL ANALYSIS OF OEDEMA 



35 



mersed in Ringer's solution approximately isotonic with nor- 

 mal resting muscle, but having a pH value of 7.0. While we 

 may recognize the fact that under certain conditions acidity 

 plays a definite role in causing muscles to take up water, it is 



TABLE 10 



Behavior of gastrocnemius muscles from frogs with red-leg disease, in Ringer's 

 solution approximately isotonic with normal resting muscle and acidulated 

 with lactic acid. 



Controls: Behavior of gastrocnemius muscles from same frogs, in Ringer's solu- 

 tion approximately isotonic with normal resting muscle. A — 0.445°. Room 

 temperature. 



evident that, within the limits indicated, its presence has no 

 material effect of this sort on the oedematous muscles from 

 red-leg frogs. It has already been pointed out by Henderson 

 ( '18), Crozier ( '18), and others that, on account of the limited 

 hydrogen-ion concentration in the body, the colloid-chemical 

 theory of Fischer is untenable. 



