38 <H UtLKN F. \V. MC CL.URE 



A generalized and excessive accumulation of lymph in the 

 subcutaneous lymph sinuses is associated chiefly with cardiac 

 inefficiency, as the result of which, when the frog remains in 

 water, more free water continuously enters the subcutaneous 

 lymph sinuses through the integument than can simultane- 

 ously be transported to the kidneys through the agency of the 

 vascular system. Hence, lymph gradually accumulates in 

 the subcutaneous lymph sinuses in excess of normal and 

 causes a general distention of the sinuses-. The osmotic pres- 

 sure of this lymph is low r er than that of normal resting muscle. 



A swelling of tissues accompanies the subcutaneous oedema. 

 This is brought about by differences in osmotic pressure 

 which exist between the fluid within and that supplied to the 

 tissues. 



