GRANULA TION-TISSUE. 



263 



through the cell-protoplasm or clustered in one spot. These 

 cells are markedly phagocytic, englobing and removing 

 bacteria, fragments of the red blood-corpuscles and proto- 

 plasmic debris generally (see Figs. 102 and 103). Another 

 variety is large and fusiform with an elongated nucleus. 



In the midst of these innumerable cellular elements run 

 newly formed capillary bloodvessels, the walls of which are 

 formed of a single layer of cells scarcely differentiated from 

 those surrounding. The exact method of the formation of 

 these new bloodvessels is as yet obscure. 



As the reparative process progresses the young spherical 

 connective-tissue cells become more angular and later fusiform. 

 As they often resemble the epithelial cells of mucous mem- 



FIG. 103. 



Phagocytes from aseptic granulations (Nikiforoff ). C, phagocytes with pseudopodia ; 

 E, without pseudopodia; F, proliferating, the daughter-nuclei in the spirem 

 phase of karyokinesis ; A, B. D, with leukocytes, fragments of tissue, and red 

 corpuscles in their cytoplasm. 



branes they are sometimes called epithelioid. To these cells, 

 which are especially consecrated to the restoration of connec- 

 tive tissue, Ziegler applies the term fibroblasts; or chondro- 

 blasts or osteoblasts if concerned in the regeneration of 

 cartilage or bone. Still further changes in shape take place, 

 until finally they become fully developed flat and slender 

 connective-tissue cells. 



Having thus rapidly attained their full development, 



