AMYLOID, LARDACEOUS, OR WAXY DEGENERATION. 279 



found on the addition of methyl- or gentian-violet, producing 

 a beautiful rose-pink, while the normal tissue stains blue. 



The changes are frequently so extensive in all the organs 

 in the body and the resulting symptoms so numerous that it 

 is often referred to as lardaceous disease. The organs most 



FIG. 113. 



Amyloid infiltration in the liver (Thorna). a, lumen of an intralobular capillary, 

 surrounded by the endothelial wall of the vessel ; b, amyloid substance imme- 

 diately beneath the endothelium ; c. epithelial cells of the hepatic parenchyma, 

 some of which show a fatty infiltration. 



frequently affected however are the liver, kidney, spleen, 

 lymphatic glands, intestinal tract and suprarenal capsules. 

 The changes begin in the inner coat of the smaller capillaries, 

 and later affect the cells and interstitial substance of the sur- 

 rounding tissue, extending along the course of the blood- 

 vessels. If extensively infiltrated, the organ is increased in 

 size ; is pale, firm, and glistening in appearance. The change 

 may be quite extensive and yet only noted on microscopical 

 examination. The parenchyma-cells of the organ swell and 

 become less angular. 



