296 PATHOLOGY OF NUTRITION. 



stage of granulation-tissue. The cells are about the size of 

 leukocytes, with large nuclei and but little cytoplasm, though 

 sometimes they are formed of larger spherical cells. There 

 is scarcely any stroma between the cells (Figs. 123 and 124). 

 The tumor is gray or pink in color, usually quite soft, and is 

 found most commonly in the skin, testicle, eye, ovary, perios- 

 teum, bone, and subcutaneous connective tissue. When they 

 occur in lymph-glands and adenoid tissue of mucous mem- 

 branes they are designated lymphosarcomata, on account of the 

 appearance of their supporting stroma. Metastasis takes 

 place through the bloodvessels, secondary growths occurring 

 most frequently in the lungs. 



Spindle-celled sarcomata have their prototype in a more 

 advanced stage of granulation-tissue the transitional stage 

 between granulation-tissue and young cicatricial tissue; the 



FIG. 125. 



Large spindle-celled sarcoma (Birch-Hirschfeld). 



cells are elongated or spindle-shaped and often irregular 

 and provided with several processes (Fig. 125). They grow 

 from dense connective tissues, as periosteum, intermuscular 

 septa, fasciae, and tendons, are firmer in consistency, and grow 

 less rapidly than the round-celled variety. The amount and 

 character of the intercellular substance in this and other types 



