84 CLINICAL BACTERIOLOGY AND 



being probably an auto -intoxication proceeding from 

 the seat of infection. 



Again, the temperature may be undisturbed, while the 

 pulse is increased, the breathing more laboured, and pul- 

 monary effusion increased, and this may be the negative 

 phase of the cycle. 



Where we are dealing with a local chronic condition, the 

 clinician is probably in a better position to judge the actual 

 state of affairs, for here we have local manifestations upon 

 which to make our observations and draw our conclusions. 

 These will be given in the succeeding chapters, as their 

 respective diseases are being dealt with. 



Although one has to use a certain amount of discretion 

 in deciding upon dosage, failure to effect a recovery may 

 solely depend upon the immunizer being too careful and 

 using too small a dose. On the other hand, we may say the 

 horse and ox in particular are very tolerant to big doses, and 

 make excellent subjects for vaccine-therapy. These con- 

 clusions have been formed after watching the effects of 

 several thousand injections. 



On the dog one has to exercise perhaps a little more 

 caution. 



Many of the vaccines advertised at the present day are 

 of little value, if only for the fact that the doses are too 

 small; we have had repeatedly to give half a dozen in one 

 before getting a suspicion of a negative phase. 



To a young colt seven days old, suffering from a 

 streptococcal infection, we have started by giving as a dose 

 100,000,000 devitalized bacteria, increasing each dose until 

 the maximum of 500,000,000 was reached. 



If a young colt can tolerate these doses, how much more 

 so an adult horse ! 



The Age of Cultures. 



Because of involution forms, one must have young 

 cultures, and endotoxins appear to be best suited for 

 vaccine-therapy purposes. 



