110 CLINICAL BACTERIOLOGY AND 



the results, but in course of time did not hesitate to give 

 a dose of 500,000,000 devitalized staphylococci to a week- 

 old foal. Of course, it should be pointed out, through 

 some idiosyncrasies of the patient itself, vaccines act less 

 seriously in some than in others; and that the vaccines 

 seem to sensitize more acutely some, while others are more 

 refractory to their effects. One must remember also some 

 vaccines possess in a pronounced degree the power of 

 disturbing the metabolism more than others. 



As soon as we are called in to a case of joint-evil, we give 

 an initial dose of the following stock vaccines, 



Streptococci 50,000,000 



Staphylococci 100,000,000 



B.coli 50,000,000 



B. pyocyaneus ... ... ... 50,000,000 



and watch the clinical symptoms. 



We then examine a scraping from the navel, aspirate 

 the joint or joints, if more than one is involved, centri- 

 fugalize and examine the deposit, cultivate the bacteria 

 present on suitable media, and make the necessary vaccine. 

 Where a joint is distended with fluid, we always insist on 

 removing it; this procedure gives the animal a better 

 chance to recover, and the after-sequelae, as has already 

 been pointed out, in the joint itself are not likely to be so 

 serious. 



If the patient is not making satisfactory progress, and 

 should a streptococcus be present, a combined vaccine and 

 serum gives good results, and should most certainly be 

 tried. 



Septicemic Arthritis in Cattle. 



This disease is only seen in cows after parturition, and, 

 in the writer's experience, in complicated parturitions, 

 either where the genital organs have been injured during 

 delivery, or where the placenta or part of the placenta 

 has been retained in utero ; in short, the condition is due 



